We are interested in identifying and understanding the cell-cell interaction is homeostasis and disease throughout the NVU.
IThe brain is one of the most complex organs in the human body. It composed from many layers and scales of complexities. The close-packed multi-cellular NVU regulates the dynamic influx and efflux of nutrients, metabolites and drugs between the systemic blood circulation and the CNS, and thereby controls brain homeostasis. Neuronal function relies on the complex interplay between molecular transport and metabolic activities within all cell populations of the NVU, and deregulation of NVU integrity results in rapid changes in brain function. To understand neuropathological states, it is therefore critical to map cell-cell interactions throughout the NVU.